Validating, augmenting and refining genome-wide association signals

@article{Ioannidis2009ValidatingAA,
  title={Validating, augmenting and refining genome-wide association signals},
  author={John P. A. Ioannidis and Gilles D. Thomas and Mark J. Daly},
  journal={Nature Reviews Genetics},
  year={2009},
  volume={10},
  pages={318-329}
}
Studies using genome-wide platforms have yielded an unprecedented number of promising signals of association between genomic variants and human traits. This Review addresses the steps required to validate, augment and refine such signals to identify underlying causal variants for well-defined phenotypes. These steps include: large-scale exact replication across both similar and diverse populations; fine mapping and resequencing; determination of the most informative markers and multiple… 
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