Validated zinc finger protein designs for all 16 GNN DNA triplet targets.

@article{Liu2002ValidatedZF,
  title={Validated zinc finger protein designs for all 16 GNN DNA triplet targets.},
  author={Qiang Liu and Z G Xia and Xiaohong Zhong and Casey C. Case},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 6},
  pages={3850-6}
}
The Cys(2)-His(2)-type zinc finger DNA-binding proteins can be engineered to bind specifically to many different DNA sequences. A single zinc finger typically binds to a 3-4-base pair DNA subsite. One strategy for design is to identify highly specific fingers that recognize each of the 64 possible DNA triplets. We started with a subgroup of the 64 triplets, the GNN-binding fingers. The GNN-binding fingers have been examined in several studies, but previous studies did not produce specific… CONTINUE READING

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