Validated quantitation of underivatized amino acids in human blood samples by volatile ion-pair reversed-phase liquid chromatography coupled to isotope dilution tandem mass spectrometry.

@article{Qu2002ValidatedQO,
  title={Validated quantitation of underivatized amino acids in human blood samples by volatile ion-pair reversed-phase liquid chromatography coupled to isotope dilution tandem mass spectrometry.},
  author={Jun Qu and Yiming Wang and Guo-An Luo and Zhuping Wu and Chengdui Yang},
  journal={Analytical chemistry},
  year={2002},
  volume={74 9},
  pages={2034-40}
}
Quantitation of amino acids in complex matrixes without derivatization is advantageous; however, difficulties exist in both the separation and the detection of those compounds. A validated method that is based on the use of volatile ion-pair liquid chromatography coupled to stable isotope dilution tandem mass spectrometry has been developed for the simple and accurate quantitation of underivatized amino acids in biological samples. Sufficient separation of 22 underivatized amino acids was… CONTINUE READING

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