Validated high-throughput screening of drug-like small molecules for inhibitors of ErbB2 transcription.

@article{Marx2006ValidatedHS,
  title={Validated high-throughput screening of drug-like small molecules for inhibitors of ErbB2 transcription.},
  author={Corina Marx and Crystal E Berger and Fan Xu and Cliff Amend and G. Kellam Scott and Byron Hann and John W. Park and Christopher C. Benz},
  journal={Assay and drug development technologies},
  year={2006},
  volume={4 3},
  pages={273-84}
}
A whole cell high-throughput screening assay was developed and tested against > 2,000 structurally and functionally diverse drug-like small molecules to identify lead compounds capable of cell permeability and selective silencing of ErbB2 transcription. Screening employed reporter sublines clonally selected from ErbB2-negative MCF7 breast cancer cells after… CONTINUE READING