Validated detection of human anti-chimeric immune responses in serum of neuroblastoma patients treated with ch14.18/CHO.

@article{Siebert2014ValidatedDO,
  title={Validated detection of human anti-chimeric immune responses in serum of neuroblastoma patients treated with ch14.18/CHO.},
  author={Nikolai Siebert and Christin Eger and Diana Seidel and Madlen J{\"u}ttner and Holger N Lode},
  journal={Journal of immunological methods},
  year={2014},
  volume={407},
  pages={
          108-15
        }
}
Human/mouse chimeric monoclonal antibody (mAb) ch14.18/CHO is directed against disialoganglioside GD2. Activity and efficacy of this mAb are currently determined in ongoing clinical Phase II and -III studies in high-risk neuroblastoma (NB). Based on the chimeric nature of this mAb, some patients may develop a human anti-chimeric immune response (Mirick et al., 2004) which impacts on pharmacokinetics and may induce anti-anti-idiotype (Id) mAb with a potential survival benefit. Therefore, a… 
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Human/mouse chimeric monoclonal antibody (mAb) ch14.18 is directed against disialoganglioside GD2 and has demonstrated activity and efficacy in high-risk neuroblastoma (NB). For the purpose of
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HAGA should not a priori preclude the therapeutic use of Ab for cancer, and studies have shown that some patients have unexpectedly prolonged survival associated with HAGA.
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Immunotherapy with ch14.18, GM-CSF, and interleukin-2 was associated with a significantly improved outcome as compared with standard therapy in patients with high-risk neuroblastoma.
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Consolidation treatment of stage 4 neuroblastoma with ch14.18 was associated with considerable but manageable side effects and Multivariate analysis failed to demonstrate an advantage of antibody treatment for EFS and OS.
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Multiple GD2-specific monoclonal antibodies have been researched over the last decade in patients diagnosed with high-risk neuroblastoma, and one anti-GD2 antibody, ch14.18, was found to significantly improve event-free and overall survival of high- Risk Neuroblastoma.
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