Validated HPLC procedures for the analysis of BMY-28090 in human plasma and urine

@article{Gaver2004ValidatedHP,
  title={Validated HPLC procedures for the analysis of BMY-28090 in human plasma and urine},
  author={R. Gaver and G. Deeb and A. M. George},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={25},
  pages={195-201}
}
SummaryThe compound BMY-28090 (elsamicin A) is a new fermentation product with antitumor properties, which has the same aglycone as chartreusin but contains two novel sugars. To define the disposition of BMY-28090 during phase I trials, HPLC procedures were developed and validated for the quantitation of the drug in human plasma and urine. To 1.0 ml plasma were added 0.5 ml 0.2M phosphate buffer (pH 8.0), 125 ng 1-naphthol (internal standard) in 25 μl MeOH and 5 ml ethyl acetate. After mixing… Expand
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