Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4

  title={Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4},
  author={Hideki Hashizume and Kiyoko Iijima and Kazuma Yamashita and Tomoyuki Kimura and Shun-Ichi Wada and Ryuichi Sawa and Masayuki Igarashi},
  journal={The Journal of Antibiotics},
In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds in the broth and designated them valgamicins A, C, T and V. The structures of these molecules were determined by spectroscopic studies, advanced Marfey’s method and X-ray crystal structural analysis. Valgamicin C contains the extremely rare amino acid cleonine. To our knowledge, this is the first report of a cleonine-containing metabolite from a naturally isolated… 
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Natural Bioactive Cyclic Peptides and Peptidomimetics

  • K. Bajaj
  • Biology, Chemistry
    Studies in Natural Products Chemistry
  • 2019

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