Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient‐initiated, double‐blind, placebo‐controlled pilot trial

  title={Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient‐initiated, double‐blind, placebo‐controlled pilot trial},
  author={Colleen Hull and Mark B. McKeough and Kate Sebastian and JD Kriesel and Spotswood L. Spruance},
  journal={Journal of the European Academy of Dermatology and Venereology},
Background  Treatment of herpes simplex labialis (HSL) has been associated with modest benefits. This difficulty results from the rapid resolution of the disease accomplished by the immune system, which narrows the window of therapeutic opportunity. The immune response is also responsible for important clinical manifestations, including oedema and pain. The dual role of immune responses (protection, pathology) is well recognized in other infectious diseases. The addition of corticosteroids to… 

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