Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient‐initiated, double‐blind, placebo‐controlled pilot trial

@article{Hull2009ValacyclovirAT,
  title={Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient‐initiated, double‐blind, placebo‐controlled pilot trial},
  author={Christopher M. Hull and Mark B. McKeough and Kate Sebastian and John D Kriesel and Spotswood L. Spruance},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2009},
  volume={23}
}
Background  Treatment of herpes simplex labialis (HSL) has been associated with modest benefits. This difficulty results from the rapid resolution of the disease accomplished by the immune system, which narrows the window of therapeutic opportunity. The immune response is also responsible for important clinical manifestations, including oedema and pain. The dual role of immune responses (protection, pathology) is well recognized in other infectious diseases. The addition of corticosteroids to… 
Acyclovir and hydrocortisone cream for the early treatment of recurrent cold sores
TLDR
A large, randomized, double-blind, placebo-controlled study recently demonstrated that treatment with 5% acyclovir-1% hydrocortisone cream significantly decreased the percentage of ulcerative lesions, reduced lesion healing time, and decreased mean lesion area compared with both topical acyClovir alone and vehicle.
Prevention of ulcerative lesions by episodic treatment of recurrent herpes labialis: A literature review.
TLDR
To critically assess published reports of episodic treatment of herpes labialis, a formulation of acyclovir/hydrocortisone showed further improvement in prevention of ulcerative lesions, while retaining efficacy with respect to lesion healing.
Current management and recommendations for access to antiviral therapy of herpes labialis.
Practical management measures for patients with recurrent herpes labialis.
TLDR
The purpose of this article is to serve as a practical guide in the management of RHL by summarizing current treatments and discussing potential new therapies.
Safety and Tolerability of Combination Acyclovir 5% and Hydrocortisone 1% Cream in Adolescents with Recurrent Herpes Simplex Labialis
TLDR
The results of this study demonstrate that the combination of AHC cream is well tolerated in the treatment of recurrent HSL in adolescents.
Terapia com ozônio no tratamento de herpes labial recorrente: relato de caso clínico
TLDR
Ozone therapy was effective in this case of recurrent herpes labialis and further studies are required to create a clinical treatment protocol.
Low-dose Oral Thimerosal for the Treatment of Oral Herpes: Clinical Trial Results and Improved Outcome After Post-hoc Analysis
TLDR
Neither clinical trial showed a statistically significant effect of BTL-TML on progression to lesion, however, the post-hoc analysis suggested there is a 48-hour period following UV radiation exposure during which the anti-herpes activity of antivirals such as BTL -TML is reduced.
Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications
TLDR
Prevalence and therapeutic studies of pediatric RHL as well as disease complications are assessed as part of efforts to evaluate therapeutic safety, tolerability, and efficacy of antivirals in the pediatric population.
Nongenital herpes simplex virus.
TLDR
The differential diagnosis of nongenital herpes simplex virus infection includes aphthous ulcers, acute paronychia, varicella-zoster virus infection, herpangina, herpes gestationis (pemphigoid gestationis), pemPHigus vulgaris, and Behçet syndrome.
...
1
2
...

References

SHOWING 1-10 OF 19 REFERENCES
Acyclovir Cream for Treatment of Herpes Simplex Labialis: Results of Two Randomized, Double-Blind, Vehicle-Controlled, Multicenter Clinical Trials
TLDR
Acyclovir cream did not prevent the development of classical lesions (progression to vesicles, ulcers, and/or crusts) and there was a statistically significant reduction in the duration of lesion pain in both studies.
Single-dose famciclovir for the treatment of herpes labialis
TLDR
Single-dose famciclovir appears to be an effective, convenient therapy for recurrent herpes labialis and the convenience of single-dose therapy may lead to better overall management of the condition.
Combination treatment with famciclovir and a topical corticosteroid gel versus famciclovir alone for experimental ultraviolet radiation-induced herpes simplex labialis: a pilot study.
TLDR
Corticosteroids in combination with an antiviral agent may be safe and beneficial for episodic treatment of herpes labialis.
Acyclovir with and without Prednisone for the Treatment of Herpes Zoster
TLDR
A clinical trial to determine the effect of adding corticosteroids to acyclovir for the treatment of herpes zoster and key study end points were measurements of pain and quality of life.
Clinical significance of antiviral therapy for episodic treatment of herpes labialis: exploratory analyses of the combined data from two valaciclovir trials.
TLDR
These exploratory analyses provide evidence of the robustness of the results to differing missing data assumptions and show that use of more clinically relevant endpoint assumptions increases the magnitude of some therapeutic responses.
Double-Blind, Randomized, Placebo-Controlled Study of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of UV Radiation-Induced Herpes Labialis
TLDR
Treatment with the combination antiviral-immunomodulatory cream provided benefit to patients with experimental UVR-induced herpes labialis, reducing classical lesion incidence, healing time, lesion size, and lesion tenderness.
Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis.
TLDR
Ocular lymphocytes recovered from eyes in the active phase of HSK were identified as Th1 cells on the basis of cytokine profile, and the possible means by which a preferential accumulation of Th1 cell occurs in the eye were discussed.
...
1
2
...