Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer.

@article{Dooley2016Val66MetBP,
  title={Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer.},
  author={Larissa N Dooley and Patricia A. Ganz and Steve W. Cole and Catherine M. Crespi and Julienne E. Bower},
  journal={Journal of affective disorders},
  year={2016},
  volume={197},
  pages={
          43-50
        }
}
BACKGROUND Inflammation contributes to the development of depression in a subset of individuals, but risk factors that render certain individuals particularly vulnerable to inflammation-associated depression are undetermined. Drawing from animal studies showing that reduced neuroplasticity mediates effects of inflammation on depression, we hypothesized that individuals genetically predisposed to lower levels of neuroplasticity would be more susceptible to inflammation-associated depression. The… CONTINUE READING

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