Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes

  title={Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes},
  author={Robert M. Senior and G L Griffin and Robert P. Mecham and D S Wrenn and K. U. Prasad and Dan W. Urry},
  journal={The Journal of Cell Biology},
  pages={870 - 874}
Recent studies have demonstrated that tropoelastin and elastin-derived peptides are chemotactic for fibroblasts and monocytes. To identify the chemotactic sites on elastin, we examined the chemotactic activity of Val-Gly-Val-Ala-Pro-Gly (VGVAPG), a repeating peptide in tropoelastin. We observed that VGVAPG was chemotactic for fibroblasts and monocytes, with optimal activity at approximately 10(-8) M, and that the chemotactic activity of VGVAPG was substantial (half or greater) relative to the… CONTINUE READING

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Cell-cell interaction in collagen biosynthesis and fibroblast

  • A. E. Postlethwaite
  • migration. Adv. Inflammation Res
  • 1983
1 Excerpt

Relationship between fibronectin mediated fibroblast chemotaxis and cell adhesion

  • J. A. McDonald, R. M. Senior, G. L. Griffin, T. J. Broekelmann, P. Prevedel
  • J. CellBiol
  • 1982
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