Vagus nerve stimulation for treatment of partial seizures: 3. Long-term follow-up on first 67 patients exiting a controlled study. First International Vagus Nerve Stimulation Study Group.

@article{George1994VagusNS,
  title={Vagus nerve stimulation for treatment of partial seizures: 3. Long-term follow-up on first 67 patients exiting a controlled study. First International Vagus Nerve Stimulation Study Group.},
  author={Rocco George and Mary Salinsky and Ruben Kuzniecky and William L. Rosenfeld and D. van. Bergen and W Brent Tarver and Joachim Wernicke},
  journal={Epilepsia},
  year={1994},
  volume={35 3},
  pages={637-43}
}
Vagus nerve stimulation (VNS) has demonstrated a significant anticonvulsant effect in preclinical studies, in pilot studies in humans, and in the acute phase of a multicenter, double-blinded, randomized study. After completion of a 14-week, blinded, randomized study, with 31 receiving high (therapeutic) VNS and 36 receiving low (less or noneffective) VNS, 67 patients elected to continue in an open extension phase. During the extension phase, all 67 patients received high VNS. Seizure frequency… CONTINUE READING

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