Vagus nerve stimulation as a tool for enhancing extinction in exposure-based therapies

@article{Noble2018VagusNS,
  title={Vagus nerve stimulation as a tool for enhancing extinction in exposure-based therapies},
  author={L. Noble and R. R. Souza and C. McIntyre},
  journal={Psychopharmacology},
  year={2018},
  volume={236},
  pages={355-367}
}
RationaleEmotionally traumatic experiences can lead to maladaptive memories that are enduring and intrusive. The goal of exposure-based therapies is to extinguish conditioned fears through repeated, unreinforced exposures to reminders of traumatic events. The extinction of conditioned fear depends upon the consolidation of new memories made during exposure to reminders. An impairment in extinction recall, observed in certain patient populations, can interfere with progress in exposure-based… Expand
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References

SHOWING 1-10 OF 174 REFERENCES
Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning.
TLDR
This protocol shows how VNS can facilitate the extinction of conditioned fear responses in an auditory fear conditioning task and provides evidence that VNS modulates synaptic plasticity in the pathway between the infralimbic medial prefrontal cortex and the basolateral complex of the amygdala, which is involved in the expression and modulation of extinction memory. Expand
The effects of transcutaneous vagus nerve stimulation on conditioned fear extinction in humans
TLDR
TVNS accelerated explicit fear extinction learning (US expectancy ratings), but did not lead to better retention of extinction memory 24h later, and was unable to assess potential effects of tVNS on the extinction of physiological indices of fear. Expand
Effects of vagus nerve stimulation on extinction of conditioned fear and post-traumatic stress disorder symptoms in rats
TLDR
Results provide evidence that extinction paired with VNS treatment can lead to remission of fear and improvements in PTSD-like symptoms and suggest that VNS may be an effective adjunct to exposure therapy for the treatment of PTSD. Expand
Pharmacological treatments that facilitate extinction of fear: Relevance to psychotherapy
TLDR
It is concluded that extinction is an excellent model system for the study of fear inhibition and an indispensable tool for the screening of putative pharmacotherapies for clinical use. Expand
Vagus nerve stimulation enhances extinction of conditioned fear and modulates plasticity in the pathway from the ventromedial prefrontal cortex to the amygdala
TLDR
The present findings suggest that VNS promotes plasticity in the IL-BLA pathway to facilitate extinction of conditioned fear responses (CFRs) in rats. Expand
Enhancing exposure therapy for anxiety disorders with glucocorticoids: from basic mechanisms of emotional learning to clinical applications.
TLDR
The processes involved in aversive conditioning, fear learning and fear extinction are examined, and how glucocorticoids might enhance restructuring of fear memories during therapy are examined. Expand
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
TLDR
Findings support the hypothesis that fear extinction is impaired in PTSD and suggest that dysfunctional activation in brain structures that mediate fear extinction learning, and especially its recall, underlie this impairment. Expand
Applying Learning Principles to the Treatment of Post‐Trauma Reactions
TLDR
There appears to be an interaction between timing of the intervention, number of intervention sessions, and either arousal level and/or risk status in determining whether the intervention will be helpful, harmful, or neutral. Expand
Rapid Remission of Conditioned Fear Expression with Extinction Training Paired with Vagus Nerve Stimulation
TLDR
VNS is a readily available and promising adjunct to exposure therapy for the treatment of severe anxiety disorders and is currently approved by the Federal Food and Drug Administration for depression and seizure prevention. Expand
Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress
TLDR
It is demonstrated that aversive fear conditioning rapidly and persistently alters spontaneous single-unit activity in the prelimbic and infralimbic subdivisions of the mPFC in behaving rats, suggesting propranolol may be a helpful adjunct to behavioral therapy for PTSD, particularly in patients who have recently experienced trauma. Expand
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