Vagus nerve stimulation (VNS) therapy update

@article{Wheless2018VagusNS,
  title={Vagus nerve stimulation (VNS) therapy update},
  author={James W. Wheless and Andrew J. Gienapp and Phillippe Ryvlin},
  journal={Epilepsy \& Behavior},
  year={2018},
  volume={88},
  pages={2-10}
}

Vagus nerve stimulation for drug-resistant epilepsy

The evidence supporting the use of VNS, its impact on seizure frequency and quality of life, and common adverse effects of this therapy are discussed and practical guidance for the approach to and the management of patients with VNS in situ is included.

Evaluating vagus nerve stimulation treatment with heart rate monitoring in pediatric patients with intractable epilepsy

This study supports the clinical safety and utility of auto-stimulation-enabled VNS models, specifically the SenTiva™ 1000, in treating pediatric patients with intractable epilepsy of various subtypes and etiologies.

Research progress of vagus nerve stimulation in the treatment of epilepsy

Vagus nerve stimulation (VNS) is one of the neuromodulation methods clinically, which have been approved by the Food and Drug Administration (FDA) and future research directions of VNS for epilepsy are described.

Vagus nerve stimulation for super-refractory status epilepticus in febrile infection–related epilepsy syndrome: a pediatric case report and literature review

A 29-month-old case is presented, diagnosed with FIRES, whose seizures were successfully controlled by utilization of VNS after ineffective response to intensive pharmacotherapy and ketogenic diet treatment.

Neuromodulation in drug‐resistant epilepsy: A review of current knowledge

Although promising outcomes in adults and children with DRE have been achieved, challenges such as heterogeneity among epilepsy types and etiologies, optimization of stimulation parameters, a lack of biomarkers to predict response to neuromodulation therapies, high‐level evidence to aid decision‐making, and direct comparisons between neurommodulatory approaches remain remain.

Vagus Nerve Stimulation Therapy for the Treatment of Seizures in Refractory Postencephalitic Epilepsy: A Retrospective Study

This study shows that VNS can reduce the frequency and severity of seizure in patients with refractory PEE and has a good application prospect in patientswith refractary PEE.

Health Technology Assessment Report on Vagus Nerve Stimulation in Drug-Resistant Epilepsy

Assessment of the clinical, organizational, financial, and economic impact of VNS therapy in drug-resistant epilepsies and the congruity between costs incurred and health service reimbursement indicates VNS as an effective treatment with a potential positive impact on social aspects and on quality of life.
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References

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Reassessment: Vagus nerve stimulation for epilepsy

A July 1997 assessment of the American Academy of Neurology Therapeutics and Technology Subcommittee review of vagus nerve stimulation for epilepsy concluded that it was promising, but not yet established, and a second multicenter, randomized, controlled clinical trial has shown safety and efficacy of VNS for treatment of intractable partial seizures.

Vagal nerve stimulation in children.

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Initial data from open-label, uncontrolled studies suggest that VNS does have some efficacy and safety for those children with refractory epilepsy who have not responded to appropriate trials of antiepileptic drugs.

Vagal nerve stimulation for refractory epilepsy in children: indications and experience at The Hospital for Sick Children

The results show that VNS implantation can be a safe and effective alternative therapy for children with drug-resistant epilepsy who are not candidates for epilepsy surgery.

Vagus nerve stimulation for treatment of epilepsy in Rett syndrome.

Quality of life outcomes of note among these patients included reports at 12 months of increased alertness among all seven patients, and VNS was safe and well tolerated, with no surgical complications and no patients requiring explantation of the device.

Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response.

In conclusion, VNS is an effective and relatively safe adjunctive therapy in patients with medically refractory epilepsy not amenable to resection, but it is important to recognize that complete seizure freedom is rarely achieved using VNS and that a quarter of patients do not receive any benefit from therapy.

Vagus nerve stimulation therapy, epilepsy, and device parameters: Scientific basis and recommendations for use

The efficacy of stimulation parameters used in the VNS clinical trials are discussed and an algorithm for the adjustment of VNS device settings is provided.

Vagus nerve stimulation (VNS) is effective in treating catastrophic 1 epilepsy in very young children

If resective surgery is inappropriate or refused, VNS can be considered as a well-tolerated and effective procedure even in toddlers affected by severe epilepsy and multiple developmental disabilities.

Vagus Nerve Stimulation for Treatment of Partial Seizures: 2. Safety, Side Effects, and Tolerability

Vagus nerve stimulation (VNS) significantly reduces the frequency of partial seizures in refractory epilepsy patients and is rated as more “improved” than those receiving low stimulation in regards to overallhealth status.

Vagus Nerve Stimulation: Clinical Experience in a Large Patient Series

Taking into account the good cost-benefit ratio as well as positive effects on well-being, VNS has to be considered an appropriate strategy for the add-on treatment of drug-resistant seizures, particularly in cases not suitable for epilepsy surgery.
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