Vagus nerve stimulation: a new tool for brain research and therapy∗

@article{George2000VagusNS,
  title={Vagus nerve stimulation: a new tool for brain research and therapy∗},
  author={Mark S. George and Harold A. Sackeim and A. John Rush and Lauren B. Marangell and Ziad Nahas and Mustafa M. Husain and Sarah H. Lisanby and Tal Burt and Juliet Goldman and James C. Ballenger},
  journal={Biological Psychiatry},
  year={2000},
  volume={47},
  pages={287-295}
}

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A July 1997 assessment of the American Academy of Neurology Therapeutics and Technology Subcommittee review of vagus nerve stimulation for epilepsy concluded that it was promising, but not yet established, and a second multicenter, randomized, controlled clinical trial has shown safety and efficacy of VNS for treatment of intractable partial seizures.

Anatomical, Physiological, and Theoretical Basis for the Antiepileptic Effect of Vagus Nerve Stimulation

The vagus provides an easily accessible, peripheral route to modulate CNS function and is likely to relate to effects on the reticular activating system.

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Long-term, open-label vagus nerve stimulation (VNS) provided seizure reduction similar to or greater than acute studies, for median reductions and for those reaching a > or =50% seizure reduction.

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