Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs.

Abstract

The motor-stimulating action of de(N-methyl)-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal (EM574) on the upper gastrointestinal tract was studied in fasted conscious dogs using chronically implanted force transducers and compared with those of porcine motilin and cisapride. EM574 induced gastric phase III-like migrating contractions and increased… (More)

Topics

Cite this paper

@article{Inatomi1996VagusdependentAV, title={Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs.}, author={Nobuhiro Inatomi and Fumio Sato and Shigetaka Marui and Zen Itoh and Satoshi O̅mura}, journal={Japanese journal of pharmacology}, year={1996}, volume={71 1}, pages={29-38} }