Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial

@article{Rush2005VagusNS,
  title={Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial},
  author={A. Rush and L. Marangell and H. Sackeim and M. George and R. Cooke},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={347-354}
}
  • A. Rush, L. Marangell, +2 authors R. Cooke
  • Published 2005
  • Medicine, Psychology
  • Biological Psychiatry
  • BACKGROUND Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS This 10-week, acute, randomized, controlled, masked trial compared adjunctive VNS with sham treatment in 235 outpatients with nonpsychotic major depressive disorder (n = 210) or nonpsychotic, depressed phase, bipolar disorder (n = 25). In the current… CONTINUE READING
    449 Citations

    Paper Mentions

    OBSERVATIONAL CLINICAL TRIAL
    This registry will collect information about patients with treatment-resistant depression (TRD) who are currently in a major depressive episode. For the purposes of this study, TRD is… Expand
    ConditionsMajor Depressive Disorder
    INTERVENTIONAL CLINICAL TRIAL
    This is a postmarket medical device study. The objective of this study is to compare the safety and effectiveness of Vagus Nerve Stimulation (VNS) Therapy administered at different… Expand
    ConditionsDepression
    InterventionDevice
    INTERVENTIONAL CLINICAL TRIAL
    To confirm the safety and efficacy of the NCP System in treating patients in a nmajor depressive episode.  
    ConditionsMajor Depressive Disorder
    InterventionDevice
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