Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial

@article{Rush2005VagusNS,
  title={Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial},
  author={A. John Rush and Lauren B. Marangell and Harold A. Sackeim and Mark S. George and Stephen K. Brannan and Sonia M. Davis and Robert H. Howland and Mitchel Allan Kling and Barry R. Rittberg and William J Burke and Mark Hyman Rapaport and John M Zajecka and Andrew A. Nierenberg and Mustafa M. Husain and David L. Ginsberg and Robert G. Cooke},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={347-354}
}
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500 Citations
Highly Influential Citations
20
Background Citations
110
Methods Citations
20
Results Citations
21

500 Citations

Vagus nerve stimulation for depression: efficacy and safety in a European study
TLDR
VNS therapy was effective in reducing severity of depression; efficacy increased over time; reduction of symptom severity was significantly higher in the European sample than previously reported.
Adjunctive vagus nerve stimulation for treatment-resistant depression: a preliminary study.
TLDR
It is indicated that adjunctive VNS was effective and safe in treating Chinese patients who were suffering from TRD, and its efficacy increased with time.
Vagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic Effects
Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
TLDR
It is shown that long-term VNS may be effective in reducing severity of depression in a small but significant minority of patients, although two patients had stimulation terminated because of adverse effects and/or refusal to continue the study.
Serial Vagus Nerve Stimulation Functional MRI in Treatment-Resistant Depression
TLDR
It is suggested that similar to other antidepressant treatments, BOLD deactivation in the ventro-medial prefrontal cortex correlates with the antidepressant response to VNS therapy.
Two-Year Outcome of Vagus Nerve Stimulation in Treatment-Resistant Depression
TLDR
The results of this 2-year open-label trial suggest a clinical response and a comparatively benign adverse effect profile among patients with treatment-resistant depression.
Transcutaneous vagus nerve stimulation for the treatment of depression: a study protocol for a double blinded randomized clinical trial
TLDR
This double-blinded randomized clinical trial has the potential to significantly extend the application of VNS treatment for MDD and other disorders (including epilepsy, bipolar disorder, and morbid obesity), resulting in direct benefit to the patients suffering from these highly prevalent disorders.
Double Blinded Randomized Trial of Subcutaneous Trigeminal Nerve Stimulation as Adjuvant Treatment for Major Unipolar Depressive Disorder.
TLDR
This study protocol is designed to define efficacy of a novel adjuvant therapy for TRD, and must strive to develop safe, reproducible, predictable, and well-tolerated neuromodulation approaches forTRD patients impaired to manage their lives and contribute with society.
Vagus nerve stimulation for chronic major depressive disorder: 12-month outcomes in highly treatment-refractory patients.
Vagus nerve stimulation for treatment-resistant depression: protocol for a pilot self-controlled trial
TLDR
The trial will provide objective data on the potential of the clinical implementation of VNS as a treatment for TRD in China and disseminate the results of the study through presentations at peer-reviewed publications.
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References

SHOWING 1-10 OF 45 REFERENCES
Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes
Vagus Nerve Stimulation (VNSâ„¢) for Treatment-Resistant Depression: Efficacy, Side Effects, and Predictors of Outcome
Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study∗ ∗ See accompanying Editorial, in this issue.
Vagus nerve stimulation is associated with mood improvements in epilepsy patients
The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression.
TLDR
Vagus nerve stimulation in treatment-resistant depression may result in enhanced neurocognitive function, primarily among patients who show clinical improvement, and controlled investigation is needed to rule out the contribution of practice effects.
Vagus nerve stimulation therapy for partial-onset seizures
TLDR
Vagus nerve stimulation is an effective and safe adjunctive treatment for patients with refractory partial-onset seizures and represents the advent of a new, nonpharmacologic treatment for epilepsy.
A Pilot Study of Mood in Epilepsy Patients Treated with Vagus Nerve Stimulation
TLDR
VNS treatment is associated with mood improvement as measured by multiple scales, but differences in mood scale scores over time between the VNS and a comparison group were not found, suggesting dissociation between seizure frequency reduction and mood change.
A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures
TLDR
VNS may be an effective alternative treatment for patients who have failed antiepileptic drug therapy and are not optimal candidates for epilepsy surgery, and largely limited to a transient hoarseness occurring during the stimulation train.
Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients
Vagus Nerve Stimulation for Treatment of Partial Seizures: 1. A Controlled Study of Effect on Seizures
TLDR
The effectiveness of VNS as treatment for epilepsy patients with refractory partial seizures was confirmed and high VNS was more effective in reducing partial seizure frequency than was low VNS.
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