Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial

@article{Rush2005VagusNS,
  title={Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial},
  author={A. John Rush and Lauren B. Marangell and Harold A. Sackeim and Mark S. George and Stephen K. Brannan and Sonia M. Davis and Robert H. Howland and Mitchel Allan Kling and Barry R. Rittberg and William J Burke and Mark Hyman Rapaport and John M Zajecka and Andrew A. Nierenberg and Mustafa M. Husain and David L. Ginsberg and Robert G. Cooke},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={347-354}
}
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TLDR
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References

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Vagus nerve stimulation is associated with mood improvements in epilepsy patients
The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression.
TLDR
Vagus nerve stimulation in treatment-resistant depression may result in enhanced neurocognitive function, primarily among patients who show clinical improvement, and controlled investigation is needed to rule out the contribution of practice effects.
Vagus nerve stimulation therapy for partial-onset seizures
TLDR
Vagus nerve stimulation is an effective and safe adjunctive treatment for patients with refractory partial-onset seizures and represents the advent of a new, nonpharmacologic treatment for epilepsy.
A Pilot Study of Mood in Epilepsy Patients Treated with Vagus Nerve Stimulation
TLDR
VNS treatment is associated with mood improvement as measured by multiple scales, but differences in mood scale scores over time between the VNS and a comparison group were not found, suggesting dissociation between seizure frequency reduction and mood change.
A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures
TLDR
VNS may be an effective alternative treatment for patients who have failed antiepileptic drug therapy and are not optimal candidates for epilepsy surgery, and largely limited to a transient hoarseness occurring during the stimulation train.
Vagus Nerve Stimulation for Treatment of Partial Seizures: 1. A Controlled Study of Effect on Seizures
TLDR
The effectiveness of VNS as treatment for epilepsy patients with refractory partial seizures was confirmed and high VNS was more effective in reducing partial seizure frequency than was low VNS.
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