• DOI:10.1016/j.biopsych.2005.05.025
Corpus ID: 22066326

Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial

@article{Rush2005VagusNS,
  title={Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial},
  author={A. Rush and L. Marangell and H. Sackeim and M. George and R. Cooke},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={347-354}
}

A. Rush, L. Marangell, +2 authors R. Cooke

Published 2005

Medicine, Psychology

Biological Psychiatry

BACKGROUND Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS This 10-week, acute, randomized, controlled, masked trial compared adjunctive VNS with sham treatment in 235 outpatients with nonpsychotic major depressive disorder (n = 210) or nonpsychotic, depressed phase, bipolar disorder (n = 25). In the current… CONTINUE READING

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