Vagus Nerve Prolonged Stimulation in Cats: Effects on Epileptogenesis (Amygdala Electrical Kindling): Behavioral and Electrographic Changes

  title={Vagus Nerve Prolonged Stimulation in Cats: Effects on Epileptogenesis (Amygdala Electrical Kindling): Behavioral and Electrographic Changes},
  author={Augusto Fern{\'a}ndez-Guardiola and A. Mart{\'i}nez and Alejandro Vald{\'e}s‐Cruz and V{\'i}ctor Manuel Magdaleno-Madrigal and D. Mart{\'i}nez and Rodrigo Fern{\'a}ndez-Mas},
Summary: Purpose: To analyze the effect of prolonged (daily) electrical vagus nerve stimulation (VNS) on daily amygdaloid kindling (AK) in freely moving cats. 

The Effect of Vagus Nerve Stimulation on Epileptiform Activity Recorded from Hippocampal Depth Electrodes

Clinical studies have established the efficacy of vagus nerve stimulation in patients with epilepsy, although the electrophysiologic effects of VNS on the human hippocampus and mesial temporal lobe structures remain unknown.

Effect of Electrical Stimulation of the Nucleus of the Solitary Tract on the Development of Electrical Amygdaloid Kindling in the Cat

The effect of electrical stimulation of the nucleus of the solitary tract (NTS) on the development of electrical amygdaloid kindling (AK) in freely moving cats is analyzed.

Preemptive effect of nucleus of the solitary tract stimulation on amygdaloid kindling in freely moving cats

The aim of this study was to analyze the preemptive effect of NTS electrical stimulation on daily amygdaloid kindling (AK) in freely moving cats.

Brain Blood Flow Alterations Induced by Therapeutic Vagus Nerve Stimulation in Partial Epilepsy: I. Acute Effects at High and Low Levels of Stimulation

Left cervical vagus nerve stimulation decreases complex partial seizures by unknown mechanisms of action and alters synaptic activities at vagal afferent terminations and in sites that receive polysynaptic projections from these medullary nuclei.

Vagus nerve stimulation.

The goal of this work is to review the history of VNS and provide information on recent advances and applications of this technology.

The Acute and Chronic Effect of Vagus Nerve Stimulation in Genetic Absence Epilepsy Rats from Strasbourg (GAERS)

This is a validated model for absence epilepsy, characterized by frequent spontaneous absences concomitant with spike and wave discharges on the EEG, which is conceptually important to investigate the efficacy of VNS in a controlled study by using this chronic epilepsy model.


The EEG background power spectra recorded from a left intracranial occipital contact were smaller with the VNS device “on” compared to when the device was “off” and VNS did not prevent or alter the course of electrographic seizures.



Neurochemical effects of vagus nerve stimulation in humans

Effects of Sleep and Sleep Stage on Epileptic and Nonepileptic Seizures

It is shown that sleep increases the frequency, duration, and secondary generalization of seizures in patients with epilepsy and in animal models of epilepsy.

Generalized convulsive seizures induced by daily electrical stimulation of the amygdala in cats

Seizure development was characterized by early distant propagation, amplitude growth of after-discharge, and development of interictal discharge along the ex-trapyramidal pathways through three distinct steps in which the mid-brain reticular formation plays a vital role in producing widespread secondary alteration and reorganization of brain function.

Chronic Vagus Nerve Stimulation Increases the Latency of the Thalamocortical Somatosensory Evoked Potential

The findings suggest that chronic vagus nerve stimulation does alter neuronal networks outside of the brain stem vagus system, and may potentially provide a means to clinically monitor and titrate this therapy.

Vagus Nerve Stimulation in Humans: Neurophysiological Studies and Electrophysiological Monitoring

Evidence from studies of experimental animals indicates that electrical stimulation of the vagus nerve alters behavioral and electrographic seizure activity and it is hoped that analysis of electrophysiological effects of vagal nerve stimulation will help elucidate which brain areas are affected.

The production of cobalt experimental epilepsy in the rat.

Anatomical, Physiological, and Theoretical Basis for the Antiepileptic Effect of Vagus Nerve Stimulation

The vagus provides an easily accessible, peripheral route to modulate CNS function and is likely to relate to effects on the reticular activating system.