Vagotomy by the local anesthetic procaine hydrochloride: a study in the rat.

  • Aws S. Salim
  • Published 1988 in Journal of pharmaceutical sciences
Transmission of nerve impulses is prevented by the local anesthetic procaine hydrochloride. This study was undertaken in rat models, in which the vagus nerve mediates gastric acid secretion, to examine the action of 1 mL of 5% oral procaine on this secretion. The H+ output (mean +/- SEM) associated with pylorus ligation for 1 h (61 +/- 7 mumol) was… CONTINUE READING