Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.

@article{CondeAgudelo2018VaginalPI,
  title={Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.},
  author={Agust{\'i}n Conde-Agudelo and Roberto Romero and Eduardo Borges da Fonseca and John M O'brien and Elcin Cetingoz and George W. Creasy and Sonia S. Hassan and Offer Erez and Percy N Pacora and Kypros H. Nicolaides},
  journal={American journal of obstetrics and gynecology},
  year={2018},
  volume={219 1},
  pages={
          10-25
        }
}
BACKGROUND An indirect comparison meta-analysis published in 2013 reported that both vaginal progesterone and cerclage are equally efficacious for preventing preterm birth and adverse perinatal outcomes in women with a singleton gestation, previous spontaneous preterm birth, and a sonographic short cervix. The efficacy of vaginal progesterone has been challenged after publication of the OPPTIMUM study. However, this has been resolved by an individual patient-data meta-analysis (Am J Obstet… CONTINUE READING
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