Vaginal progesterone in women with twin gestations complicated by short cervix: a retrospective cohort study

@article{Brubaker2015VaginalPI,
  title={Vaginal progesterone in women with twin gestations complicated by short cervix: a retrospective cohort study},
  author={Sara G. Brubaker and Cara Pessel and Noelia M. Zork and Cynthia Gyamfi‐Bannerman and Cande V. Ananth},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={2015},
  volume={122},
  pages={712 - 718}
}
To determine whether the use of vaginal progesterone in twin gestations with a cervical length (CL) of ≤2.5 cm is associated with a reduced risk of preterm delivery. 
Effect of vaginal progesterone in combination with cervical cerclage on improved gestational age and perinatal outcome in twin pregnancy: A prospective randomized study
TLDR
Several randomized studies have provided an evidence that progesterone supplementation can result in significant reduction of preterm birth and neonatal morbidity and mortality and cervical cerclage has reduced the risk of pre term labour for selected population of singleton pregnancies. Expand
Cervical Pessary Plus Progesterone for Twin Pregnancy with Short Cervix Compared to Unselected and Non-Treated Twin Pregnancy: A Historical Equivalence Cohort Study (EPM Twin Pessary Study).
  • M. S. França, A. Hatanaka, +6 authors A. Moron
  • Medicine
  • Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
  • 2020
TLDR
In DC-DA twin pregnancies with a short cervix, the treatment with cervical pessary plus progesterone could be considered equivalent in several aspects related to PB in the NTG, despite the big difference between these groups. Expand
Does cervical cerclage decrease preterm birth in twin pregnancies with a short cervix?
TLDR
Cerclage placement for cervical length ≤2.5 cm in twin gestations with mid-trimester short cervix did not decrease the rate of preterm birth at <35 weeks; however, cerclage placements for cervicallength was associated with a significantly decreased rate ofPreterm birth<35 weeks when compared to patients managed without cerclages. Expand
Use of natUral micronized progesterone in the prevention of preterm labor in twin pregnancies
TLDR
The use of natural micronized progesterone did not reduce the frequency of preterm birth in twin pregnancies, and there was no association between use of progester one and delivery time. Expand
Measuring the Cervical Length
TLDR
The correct technique for obtaining measurements for preterm birth is described and the literature regarding the use of this tool in specific pregnant populations is reviewed. Expand
The effect of early administration of rectal progesterone in IVF/ICSI twin pregnancies on the preterm birth rate: a randomized trial
TLDR
Rectal natural progesterone starting from the first trimester in IVF/ICSI twin pregnancies did not reduce spontaneous preterm birth and progesterone administration was not associated with a significant decrease. Expand
Efficacy of midtrimester short cervix interventions is conditional on intraamniotic inflammation.
TLDR
Cerclage placement or administration of 17OHP-C therapy for midtrimester short cervix for PTD prevention appears beneficial only in the subset of patients with high inflammation. Expand
Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety.
TLDR
Evidence from a single large comparative efficacy trial suggests that vaginal natural progesterone is superior to 17-hydroxyprogesterone caproate as a prophylactic treatment in women with a history of mid-trimester preterm birth, and the synthetic drug is contraindicated in this population. Expand
Progestogen safety in multiple gestations: application of the Bradford Hill criteria
  • J. O'brien
  • Medicine
  • BJOG : an international journal of obstetrics and gynaecology
  • 2015
TLDR
A recently published individual participant data meta-analysis (IPDMA) involving twin gestations also identified a significant increase in a composite of perinatal death plus severe neonatal morbidities in important subgroups exposed to 17–OHPC. Expand

References

SHOWING 1-10 OF 34 REFERENCES
Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo‐controlled trial on the effect of vaginal micronized progesterone
TLDR
This study investigated the preventive effect of vaginal micronized progesterone in a large population of twin gestations and found it to have a protective effect on preterm delivery. Expand
Effect of progesterone on cervical shortening in women at risk for preterm birth: secondary analysis from a multinational, randomized, double‐blind, placebo‐controlled trial
  • J. O'brien, E. DeFranco, +5 authors G. Creasy
  • Medicine
  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2009
TLDR
To determine whether progesterone supplementation alters cervical shortening in women at increased risk for preterm birth, data are drawn on women who have given birth to twins or have had at-risk pregnancies. Expand
Vaginal micronized progesterone and risk of preterm delivery in high‐risk twin pregnancies: secondary analysis of a placebo‐controlled randomized trial and meta‐analysis
TLDR
Progesterone treatment reduces the risk of preterm delivery in high‐risk singleton pregnancies and the preventive effect of vaginal progesterone in high-risk twins is evaluated. Expand
Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double‐blind, placebo‐controlled trial
  • S. Hassan, R. Romero, +22 authors G. Creasy
  • Medicine
  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2011
TLDR
The efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix is determined. Expand
Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double‐blind multicentre trial
TLDR
The aim was to determine the efficacy and safety of two different daily doses of vaginal natural progesterone, compared with placebo, for preventing preterm birth in unselected twin pregnancies. Expand
Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data.
TLDR
Vaginal progesterone administration to asymptomatic women with a sonographic short cervix in the midtrimester reduces the risk of preterm birth and neonatal morbidity and mortality. Expand
Second trimester cervical length and risk of preterm birth in women with twin gestations treated with 17-α hydroxyprogesterone caproate
  • C. Durnwald, V. Momirova, +13 authors C. Spong
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2010
TLDR
A cervical length above the 75th percentile at 16–20 weeks did not significantly reduce the risk of preterm birth in this high risk population of women, and 17 OHPC did not prevent pre term birth before 35 weeks gestation. Expand
Progesterone and the risk of preterm birth among women with a short cervix.
TLDR
In women with a short cervix, treatment with progesterone reduces the rate of spontaneous early preterm delivery and is associated with a nonsignificant reduction in neonatal morbidity. Expand
Prevention of preterm delivery by 17 alpha-hydroxyprogesterone caproate in asymptomatic twin pregnancies with a short cervix: a randomized controlled trial.
TLDR
Twice-weekly injections of 17P did not prolong pregnancy significantly in asymptomatic women with a twin pregnancy and short cervix, and treatment with 17P was associated with a significant increase in the rate of preterm delivery before 32 weeks. Expand
Transvaginal sonographic cervical length for the prediction of spontaneous preterm birth in twin pregnancies: a systematic review and metaanalysis.
TLDR
Transvaginal sonographic CL at 20-24 weeks' gestation is a good predictor of spontaneous preterm birth in asymptomatic women with twin pregnancies. Expand
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