Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells.

@article{Ballweber2011VaginalLC,
  title={Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells.},
  author={Lamar Ballweber and B. Robinson and Allison C Kreger and Michael F. Fialkow and Gretchen M Lentz and M Juliana McElrath and Florian Hladik},
  journal={Journal of virology},
  year={2011},
  volume={85 24},
  pages={13443-7}
}
Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4+ T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a… CONTINUE READING
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