Vaginal immunization against induced cystitis in monkeys.


Cynomolgus monkeys received either vaginal immunization with formalin-killed E. coli or vaginal instillation of excipient without the bacteria. At 2, 7, 14 and 21 days after induction of a urinary tract infection with live E. coli, immunized monkeys showed enhanced clearance of bacteriuria compared to non-immunized controls. Immunized monkeys also showed increased levels of urinary anti-E. coli IgA and IgG after the immunizing and infecting procedures. Induction of heightened local immunity by vaginal immunization may lessen host susceptibility to urinary tract infections.


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@article{Uehling1987VaginalIA, title={Vaginal immunization against induced cystitis in monkeys.}, author={David T. Uehling and Walter J. Hopkins and Jeffrey L. Jensen and Edward J Balish}, journal={The Journal of urology}, year={1987}, volume={137 2}, pages={327-9} }