Vaginal fetal fibronectin as a predictor of spontaneous preterm delivery in triplet gestations

@article{Roman2012VaginalFF,
  title={Vaginal fetal fibronectin as a predictor of spontaneous preterm delivery in triplet gestations},
  author={A. Roman and C. Pessel and N. Fox and C. Klauser and D. Saltzman and A. Rebarber},
  journal={The Journal of Maternal-Fetal \& Neonatal Medicine},
  year={2012},
  volume={25},
  pages={1921 - 1923}
}
Objective: To assess the diagnostic accuracy of vaginal fetal fibronectin (fFN) sampling for predicting preterm birth in asymptomatic women carrying triplet gestations. Methods: An historical cohort of patients carrying triplet gestations between 1998 and 2010 was identified from a single practice by chart review. All patients were screened with fFN testing at 2–3 week intervals from 22 weeks to 32 weeks of gestation. Outcomes evaluated were spontaneous preterm birth prior to 28, 30, and 32… Expand
Combined fetal fibronectin and cervical length and spontaneous preterm birth in asymptomatic triplet pregnancies
  • N. Fox, A. Rebarber, A. Roman, C. Klauser, D. Peress, D. Saltzman
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2012
TLDR
In asymptomatic women with triplet pregnancies, f FN and CL are each significantly associated with SPTB, and combined fFN and CL testing outperforms either test alone for the prediction of SPTB. Expand
Fetal fibronectin as a biomarker of preterm labor: a review of the literature and advances in its clinical use.
TLDR
The development of a bedside quantitative fFN test has shown promise to further improve the positive predictive abilities of fFN, as have combined predictive models with cervical length and fFN. Expand
Fetal fibronectin, cervical length, and the risk of preterm birth in patients with an ultrasound or physical exam indicated cervical cerclage
TLDR
In patients with an ultrasound or physical exam indicated cerclage, a positive fFN and a short CL are both associated with preterm birth, and the risk of pre term birth increases with the number of abnormal biomarkers. Expand
The greater risk of preterm birth in triplets is mirrored by a more rapid cervical shortening along gestation.
TLDR
The higher rate of preterm birth in triplet pregnancies, compared with twin pregnancies, is reflected by both a more rapid cervical shortening during gestation and a lower gestational age at birth per any given cervical length. Expand
The fetal fibronectin test: 25 years after its development, what is the evidence regarding its clinical utility? A systematic review and meta-analysis
  • G. Faron, L. Balepa, J. Parra, J. Fils, L. Gucciardo
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2018
TLDR
The performance of the fetal fibronectin test was also too low to be clinically relevant, and the best use policy probably still depends on local contingencies, future cost-effectiveness analysis, and comparison with other more recent available biochemical markers. Expand
Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta‐analysis
Fetal fibronectin (fFN) is a validated test for assessing risk of preterm birth for women presenting with symptoms. Our aim was to evaluate the accuracy of fFN to detect the risk of preterm birth inExpand
Outils prédictifs de l’accouchement prématuré dans une population asymptomatique à haut risque
TLDR
Un enregistrement regulier de l’activite uterine ainsi que les visites a domicile pour une population asymptomatique a haut risque ne permettent pas of predire ni of reduire le risque d’accouchement premature. Expand

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Fetal fibronectin as a predictor of spontaneous preterm delivery in triplet gestations
  • Sensitivity Specificity PPV NPV Positive LR