Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis.

@article{Yano2014VaginalEC,
  title={Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis.},
  author={Junko Yano and Glen E. Palmer and Karen E. Eberle and Brian Mitchell Peters and Thomas Vogl and Andrew N. J. McKenzie and Paul L. Fidel},
  journal={Infection and immunity},
  year={2014},
  volume={82 2},
  pages={783-92}
}
Vulvovaginal candidiasis (VVC), caused by Candida albicans, affects women worldwide. Animal and clinical studies suggest that the immunopathogenic inflammatory condition of VVC is initiated by S100 alarmins in response to C. albicans, which stimulate polymorphonuclear neutrophil (PMN) migration to the vagina. The purpose of this study was to extend previous in vitro data and determine the requirement for the alarmin S100A8 in the PMN response and to evaluate pattern recognition receptors (PRRs… CONTINUE READING
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