Vaginal delivery of protein drugs in rats by gene-transformed Lactococcus lactis.

Abstract

A probiotic bacterium, Lactococcus lactis subsp. lactis (L. lactis) transformed with plasmid ss80, which made it capable of synthesizing and secreting β-lactamase, a 29 kDa protein, was used to deliver β-lactamase via vaginal route. The vaginal absorption of β-lactamase in rats was studied when delivered by this L. lactis system and compared to the… (More)

Topics

4 Figures and Tables

Slides referencing similar topics