Vaginal Mesh for Prolapse: A Randomized Controlled Trial

@article{Iglesia2010VaginalMF,
  title={Vaginal Mesh for Prolapse: A Randomized Controlled Trial},
  author={Cheryl Bernadette Iglesia and Andrew Ian Sokol and Eric R. Sokol and Bela I. Kudish and Robert Eric Gutman and Joanna L. Peterson and Susan Shott},
  journal={Obstetrics \& Gynecology},
  year={2010},
  volume={116},
  pages={293-303}
}
OBJECTIVE: To present 3-month outcomes of a double-blind, multicenter randomized controlled trial comparing traditional vaginal prolapse surgery without mesh with vaginal surgery with mesh. METHODS: Women with pelvic organ prolapse quantification prolapse stages 2–4 were randomized to vaginal colpopexy repair with mesh or traditional vaginal colpopexy without mesh. The primary outcome measure was objective treatment success (pelvic organ prolapse quantification stage 1 or lower) at 3 months… 
Three-Year Outcomes of Vaginal Mesh for Prolapse: A Randomized Controlled Trial
TLDR
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TLDR
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TLDR
Patient goal attainment after vaginal prolapse repair was high and not consistently related to objective anatomical outcome or mesh use, but persisted between 3 and 12 months postoperatively and was associated with better satisfaction, quality of life, and symptom scores.
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TLDR
Prosthetic repair should be used for therapeutic purposes in patients with vaginal vault recurrence and considered at vaginal hysterectomy only in selected subjects with complete utero-vaginal eversion.
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TLDR
It is found that trocar guided transvaginal mesh of anterior vaginal wall prolapse resulting in a lowering of maximal urethral closing pressures (MUCP) and increased risk for de novo stress urinary incontinence compared to colporraphy.
Surgery for women with apical vaginal prolapse.
TLDR
The safety and efficacy of any surgical intervention compared to another intervention for the management of apical vaginal prolapse is evaluated and no conclusive evidence that vaginal procedures increaserepeat surgery for stress urinary incontinence (SUI) is found.
Vaginal prolapse repair using the Prolift kit: a registry of 100 successive cases.
Native tissue repair or transvaginal mesh for recurrent vaginal prolapse: what are the long-term outcomes?
TLDR
Although the success rate is better with the use of TVM for recurrent prolapse, the total re-operation rates are similar when mesh complication-related surgeries are included and the overallRe-operation rate was not significantly different when procedures to correct mesh complications were included.
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References

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Outcome After Anterior Vaginal Prolapse Repair: A Randomized Controlled Trial
TLDR
Anterior vaginal prolapse repair with polypropylene mesh reinforcement offers lower anatomic recurrence than anterior colporrhaphy at one year, however, quality of life and sexual symptoms scores improved in both groups.
Low-Weight Polypropylene Mesh for Anterior Vaginal Wall Prolapse: A Randomized Controlled Trial
TLDR
Anterior colporrhaphy, reinforced with, tailored mesh significantly reduced the rate of recurrence of anterior vaginal wall prolapse compared with the traditional operation, but was associated more often with stress urinary incontinence.
Total transvaginal mesh (TVM) technique for treatment of pelvic organ prolapse: a 3-year prospective follow-up study
TLDR
Medium-term results demonstrate that the TVM technique provides a durable prolapse repair, and is effective in patients with prolapse ≥stage II.
Short-term outcome after transvaginal mesh repair of pelvic organ prolapse
TLDR
This first report from an ongoing multicenter study suggests that transvaginal mesh surgery with the Prolift® system is associated with satisfactory outcomes 2 months after surgery, and all quality of life aspects measured by the IIQ-7 improved 2  Months after surgery.
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TLDR
According to the perioperative and immediate post-operative results, Prolift™ repair seems to be a safe technique to correct pelvic organ prolapse and Anatomical and functional results must be assessed with long-term follow-up to confirm the effectiveness and safety of the procedure.
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TLDR
Women undergoing transvaginal repair of POP with the Prolift® mesh system showed significant improvement in 1-year anatomic and subjective measures.
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TLDR
The rate of complications requiring reoperation and the total reoperation rate was highest for vaginal mesh kits despite a lower re operation rate for prolapse recurrence and shorter overall follow-up.
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TLDR
The results suggest that the Apogee® and Perigee® repair systems (monofilament polypropylene mesh) yield excellent short-term results after 1 year.
Graft Use in Transvaginal Pelvic Organ Prolapse Repair: A Systematic Review
TLDR
Overall, the existing evidence is limited to guide decisions regarding whether to use graft materials in transvaginal prolapse surgery and adequately powered randomized trials evaluating anatomic and symptomatic efficacy as well as adverse events are needed.
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