Vagal stimulation during muscarinic and beta-adrenergic blockade increases atrial contractility and heart rate.

@article{Henning1992VagalSD,
  title={Vagal stimulation during muscarinic and beta-adrenergic blockade increases atrial contractility and heart rate.},
  author={Robert J. Henning},
  journal={Journal of the autonomic nervous system},
  year={1992},
  volume={40 2},
  pages={121-9}
}
We determined the effects of continuous cardiac vagal nerve stimulation on atrial contractility and on heart rate in mongrel dogs in which we blocked the muscarinic and beta-adrenergic receptors. Each dog received atropine, 0.5 mg/kg and propranolol, 0.5-1 mg/kg. We stimulated the cardiac vagus nerves in each dog for three separate 5-min periods at frequencies of 0 (control), 20, and 40 Hz (5 ms, 15 V) and measured the changes in atrial contractility and heart rate. Vagal nerve stimulation… CONTINUE READING