Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.

  title={Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.},
  author={Shigeo Nishi and Yutaka Seino and Hitoshi Ishida and Michiyo Seno and Tomohiko Taminato and Hideo Sakurai and Hiroo Imura},
  journal={The Journal of clinical investigation},
  volume={79 4},
Using a new in vitro procedure of the isolated perfused rat pancreas with vagal innervation, electrical vagal stimulation produced an increase in both insulin and glucagon secretion in proportion to the pulse frequency, but an inhibition in somatostatin release. When atropine was infused, both insulin and glucagon responses to vagal stimulation were partially suppressed, whereas somatostatin release was enhanced. In the presence of hexamethonium, vagal stimulation failed to affect insulin… 

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