Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.
@article{Nishi1987VagalRO, title={Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat.}, author={Shigeo Nishi and Yutaka Seino and Hitoshi Ishida and Michiyo Seno and Tomohiko Taminato and Hideo Sakurai and Hiroo Imura}, journal={The Journal of clinical investigation}, year={1987}, volume={79 4}, pages={ 1191-6 } }
Using a new in vitro procedure of the isolated perfused rat pancreas with vagal innervation, electrical vagal stimulation produced an increase in both insulin and glucagon secretion in proportion to the pulse frequency, but an inhibition in somatostatin release. When atropine was infused, both insulin and glucagon responses to vagal stimulation were partially suppressed, whereas somatostatin release was enhanced. In the presence of hexamethonium, vagal stimulation failed to affect insulin…
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References
SHOWING 1-10 OF 28 REFERENCES
Autonomic nervous control of pancreatic somatostatin secretion.
- Biology, MedicineThe American journal of physiology
- 1983
Both divisions of the autonomic nerve supply to the pancreas are inhibitory to somatostatin secretion, but increased secretion may be brought about by a beta-adrenergic mechanism.
Nervous control of pancreatic endocrine secretion in pigs. I. Insulin and glucagon responses to electrical stimulation of the vagus nerves.
- Medicine, BiologyActa physiologica Scandinavica
- 1981
The increases in the concentrations of insulin and pancreatic glucagon in portal venous and arterial plasma in response to electrical stimulation of the vagus nerves were studied in anesthetized…
Effect of Vagotomy and Vagal Stimulation on Insulin Secretion
- Medicine, BiologyDiabetes
- 1967
The influence of the vagus nerve on insulin secretion in the dog has been confirmed by studies involving both vagotomy and vagal stimulation and only a portion of releasable insulin appears to be under vagal control.
Glucagon release induced by pancreatic nerve stimulation in the dog.
- Medicine, BiologyThe Journal of clinical investigation
- 1973
A direct neural role in the regulation of immunoreactive glucagon (IRG) secretion has been investigated during stimulation of mixed autonomic nerves to the pancreas in anesthetized dogs. The…
Neural regulation of insulin secretion in the dog.
- Biology, MedicineThe Journal of clinical investigation
- 1973
It is concluded that the nerve supply to the endocrine pancreas of the dog is sufficient to inhibit insulin secretion by activation of the sympathetic nerves and to stimulate pancreatic secretion byactivation of the parasympathetic nerves.
Starvation-induced Changes of Somatostatin, Glucagon, and Insulin Secretion from the Isolated Perfused Rat Pancreas
- Biology, MedicineDiabetes
- 1980
It is concluded that fasting causes a decrease in basal pancreatic somatostatin secretion in vitro, although the response to arginine is rather exaggerated.
Stimulation of insulin and glucagon secretion by vasoactive intestinal peptide.
- Biology, MedicineThe American journal of physiology
- 1977
The studies indicate the VIP present in pancreatic islets might play a role in the local control of pancreatic endocrine function.
Pancreatic endocrine responses to stimulation of the peripheral ends of the vagus nerves in conscious calves.
- Medicine, BiologyThe Journal of physiology
- 1981
Vagal stimulation caused a prompt increase in the concentrations of pancreatic glucagon, insulin and pancreatic polypeptide in the arterial plasma and this response was found to persist in the presence of atropine.
Effect of neurotensin on insulin, glucagon, and somatostatin release from isolated pancreatic islets.
- Biology, MedicineEndocrinology
- 1979
It is concluded that neurotensin exerts a dual effect on the endocrine pancreas in vitro: 1) at low glucose concentration and over short term (20 min) incubations, the peptide stimulates insulin, glucagon, and somatostatin release; and 2) under stimulated conditions (high glucose or arginine), neurotensIn inhibits insulin, glucose, glucagons, and Somatostasin release.
A quantitative study of the insulin release induced by vagal stimulation in anesthetized cats.
- Medicine, BiologyActa physiologica Scandinavica
- 1978
Vagal stimulation of either the right or the left cervical vagus released the same amount of insulin, whereas bilateral stimulation released twice as much, and with shorter interstimulatory periods the amounts of insulin released were reduced.