Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow

@inproceedings{Uitterdijk2015VagalNS,
  title={Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow},
  author={Andr{\'e} Uitterdijk and Tuncay Yetgin and Maaike te Lintel Hekkert and Stefan Sneep and Ilona Krabbendam-Peters and Heleen M. M. van Beusekom and Trent M. Fischer and Richard N M Cornelussen and Olivier Christiaan Manintveld and Daphne Merkus and Dirk J. Duncker},
  booktitle={Basic Research in Cardiology},
  year={2015}
}
Vagal nerve stimulation (VNS) started prior to, or during, ischemia has been shown to reduce infarct size. Here, we investigated the effect of VNS when started just prior to, and continued during early, reperfusion on infarct size and no-reflow and studied the underlying mechanisms. For this purpose, swine (13 VNS, 10 sham) underwent 45 min mid-LAD occlusion followed by 120 min of reperfusion. VNS was started 5 min prior to reperfusion and continued until 15 min of reperfusion. Area at risk… CONTINUE READING