Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders

@article{Broncel2020VagalNS,
  title={Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders},
  author={Adam Broncel and Renata Bocian and Paulina Kłos-Wojtczak and Kamila Kulbat-Warycha and Jan Konopacki},
  journal={Brain Research Bulletin},
  year={2020},
  volume={155},
  pages={37-47}
}
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28 Citations
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28 Citations

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Evidence of the critical involvement of NE in the antiepileptic effects of VNS in rodents and humans is reported and the hypothesis that the functional integrity of the noradrenergic system could be a determining factor to obtain clinical benefits from the therapy is emphasized.

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Effects of Noninvasive Cervical Vagal Nerve Stimulation on Cognitive Performance But Not Brain Activation in Healthy Adults.

It is hypothesized that nVNS increased attention compared to sham, and that this effect led to enhanced executive functions, and consequently to better performance on visuospatial reasoning and recognition tasks.

Transcutaneous Vagus Nerve Stimulation (tVNS) Improves High-Confidence Recognition Memory but Not Emotional Word Processing

Whereas tVNS showed no effects on word processing, subtle effects on recollection-based memory performance emerged, which may indicate that tV NS facilitates hippocampus-mediated consolidation processes.

Controllability of the vagus nerve using directed electrode stimulation

The preliminary results of this study corroborate the concept of selectively targeting regions of the nerve with electrical stimulation in order to treat specific patient needs and could be employed as a planning tool prior to the geometrical design and surgical implantation of VNS devices.

“The Wandering Nerve Linking Heart and Mind” – The Complementary Role of Transcutaneous Vagus Nerve Stimulation in Modulating Neuro-Cardiovascular and Cognitive Performance

T-VNS offers exciting potential as a therapeutic intervention in cognitive decline and aging populations, classically affected by reduced cerebral perfusion by modulating both limbic and frontal cortical structures, regulating cerebral perfusions and improving parasympathetic modulation of the cardiovascular system.

Effects and neuroprotective mechanisms of vagus nerve stimulation on cognitive impairment with traumatic brain injury in animal studies: A systematic review and meta-analysis

The present review showed that VNS can effectively promote cognitive impairment and neuropathology in animal models of TBI and there is a need for high-quality TBI animal studies with sufficient sample size and a more comprehensive outcome evaluation.

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