Vagal control of the heart: central serotonergic (5-HT) mechanisms.

  title={Vagal control of the heart: central serotonergic (5-HT) mechanisms.},
  author={David L. Jordan},
  journal={Experimental physiology},
  volume={90 2},
Cardiac vagal preganglionic neurones (CVPNs) are located within the dorsal vagal nucleus (DVN) and the nucleus ambiguus (nA). In mammals, CVPNs within the nA have small myelinated axons and mediate major chronotropic effects, those in the DVN have non-myelinated axons and mediate smaller chronotropic, dromotropic and inotropic effects. Numerous studies demonstrate important influences of serotonin (5-HT) at multiple sites controlling autonomic outflows including the nucleus tractus solitarius… CONTINUE READING
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