Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion.

@article{Li1993VagalAP,
  title={Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion.},
  author={Y. Li and Chung Owyang},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 1},
  pages={418-24}
}
To establish the mechanism(s) and site(s) of action of cholecystokinin (CCK) on pancreatic secretion under physiological conditions, we used an in vivo model using anesthetized rats with pancreaticobiliary cannulas. Infusion of CCK-8 (10-160 pmol/kg per h) produced a dose-dependent increase in plasma CCK levels. CCK-8 infusion at 40 pmol/kg per h produced a plasma CCK level of 7.9 +/- 1.5 pM and an 80% increase in pancreatic protein output over basal. This level was closely approximated by a… CONTINUE READING
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