Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion.

@article{Li1993VagalAP,
  title={Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion.},
  author={Yong Li and Chung Owyang},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 1},
  pages={
          418-24
        }
}
  • Yong Li, Chung Owyang
  • Published 1993
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • To establish the mechanism(s) and site(s) of action of cholecystokinin (CCK) on pancreatic secretion under physiological conditions, we used an in vivo model using anesthetized rats with pancreaticobiliary cannulas. Infusion of CCK-8 (10-160 pmol/kg per h) produced a dose-dependent increase in plasma CCK levels. CCK-8 infusion at 40 pmol/kg per h produced a plasma CCK level of 7.9 +/- 1.5 pM and an 80% increase in pancreatic protein output over basal. This level was closely approximated by a… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 123 CITATIONS, ESTIMATED 47% COVERAGE

    Central CGRP inhibits pancreatic enzyme secretion by modulation of vagal parasympathetic outflow.

    VIEW 6 EXCERPTS
    CITES METHODS, BACKGROUND & RESULTS

    Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion.

    VIEW 3 EXCERPTS
    CITES BACKGROUND & RESULTS

    Ghrelin acts on the dorsal vagal complex to stimulate pancreatic protein secretion.

    VIEW 18 EXCERPTS
    CITES BACKGROUND, METHODS & RESULTS

    Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats.

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    Effects of M1 and CCK antagonists on latency of pancreatic amylase response to intestinal stimulants.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Supramaximal CCK-58 does not induce pancreatitis in the rat: role of pancreatic water secretion.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    1994
    2020

    CITATION STATISTICS

    • 3 Highly Influenced Citations

    • Averaged 5 Citations per year from 2018 through 2020