Vagal Paraganglia Bind Biotinylated Interleukin-1 Receptor Antagonist: A Possible Mechanism for Immune-to-Brain Communication

@article{Goehler1997VagalPB,
  title={Vagal Paraganglia Bind Biotinylated Interleukin-1 Receptor Antagonist: A Possible Mechanism for Immune-to-Brain Communication},
  author={Lisa Elane Goehler and Jane K. Relton and David Dripps and Rachel Kiechle and Nicole Tartaglia and Steven F. Maier and Linda R. Watkins},
  journal={Brain Research Bulletin},
  year={1997},
  volume={43},
  pages={357-364}
}
Interleukin-1 beta is a proinflammatory cytokine released by activated immune cells. In addition to orchestrating immune responses to infection, interleukin-1 beta is a key mediator of immune-to-brain communication. Interleukin-1 beta and endotoxin (which releases IL1 beta from immune cells) cause centrally mediated illness responses such as fever, aphagia, etc. These effects are blocked by intraperitoneal IL1 receptor antagonist (IL1ra), suggesting critical involvement of peripheral IL1… CONTINUE READING
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