Vagal Paraganglia Bind Biotinylated Interleukin-1 Receptor Antagonist: A Possible Mechanism for Immune-to-Brain Communication

@article{Goehler1997VagalPB,
  title={Vagal Paraganglia Bind Biotinylated Interleukin-1 Receptor Antagonist: A Possible Mechanism for Immune-to-Brain Communication},
  author={Lisa E. Goehler and Jane K. Relton and David Dripps and Rachel Kiechle and N Tartaglia and Steven F. Maier and Linda R. Watkins},
  journal={Brain Research Bulletin},
  year={1997},
  volume={43},
  pages={357-364}
}
Interleukin-1β in Immune Cells of the Abdominal Vagus Nerve: a Link between the Immune and Nervous Systems?
TLDR
A novel mechanism by which IL-1β may serve as a molecular link between the immune system and vagus nerve, and thus the CNS is suggested.
Activation of Vagal Afferents after Intravenous Injection of Interleukin-1β: Role of Endogenous Prostaglandins
TLDR
Evidence is presented that somata and/or fibers of sensory neurons of the vagus nerve express receptors to IL-1 and prostaglandin E2 and that circulating IL- 1 stimulates vagal sensory activity via both prostag landin-dependent and -independent mechanisms.
Strong Expression of Interleukin-1 Receptor Type I in the Rat Carotid Body
  • Xi Wang, Bai-ren Wang, G. Ju
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 2002
TLDR
The results imply that the carotid body not only serves as a chemoreceptor for modulation of cardiorespiratory performance, as traditionally recognized, but also acts as a cytokine chemorereceptor for sensing immune signals.
Up-regulation of IL-1 receptor type I and tyrosine hydroxylase in the rat carotid body following intraperitoneal injection of IL-1β
TLDR
The aim of this study was to observe the changes in expression of IL-1RI and tyrosine hydroxylase (TH), a rate-limiting enzyme for catecholamine synthesis, in the glomus cells of the rat carotid body following intraperitoneal injection ofIL-1β.
The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose.
TLDR
It is suggested that low doses of intraperitoneal IL-1beta induce fever via a vagal route and that dose may account for some of the discrepancies in the literature.
Cytokines and fever.
TLDR
The mechanisms that ultimately mediate the central action of cytokines and of LPS on the temperature-sensitive neurons in the preoptic hypothalamic region involved in thermoregulation, directly or via second mediators, remain to be fully elucidated.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Receptors for interleukin-1 in the central nervous and neuroendocrine systems. Role in infection and stress.
TLDR
The functional interactions between the Immune and the Central Nervous Systems (CNS) are clearly indicated by the fact these systems are sharing mediators and receptors, suggesting that IL-1 synthesis is not modulated by glucocorticoids in the CNS as in the immune system.
The Role of the Vagus Nerve in Cytokine‐to‐Brain Communication
TLDR
Data are reviewed that indicate that at least some of the CNS response to peripheral IL‐1β are instead mediated by a neural route of communication between the periphery and the CNS.
Biology of interleukin 1
  • C. Dinarello
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1988
TLDR
IL 1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites and acts synergistically with other cytokines, particularly tumor necrosis factor.
A complete regulatory loop between the immune and neuroendocrine systems.
TLDR
Infection of lymphocytes with Newcastle disease virus induces the cells to synthesize immunoreactive (ir) adrenocorticotropin (ACTH) and endorphins, and lymphocytes were shown to have high-affinity receptors for both of these hormones.
...
1
2
3
4
5
...