Vacuum‐Assisted Closure: A New Method for Wound Control and Treatment: Animal Studies and Basic Foundation

@article{Morykwas1997VacuumAssistedCA,
  title={Vacuum‐Assisted Closure: A New Method for Wound Control and Treatment: Animal Studies and Basic Foundation},
  author={Michael J. Morykwas and Louis C. Argenta and Erica I. Shelton-Brown and Wyman T. McGuirt},
  journal={Annals of Plastic Surgery},
  year={1997},
  volume={38},
  pages={553–562}
}
A series of basic animal studies using a new subatmospheric pressure technique (The V.A.C.) to expedite wound healing are presented. The technique entails placing an open-cell foam into the wound, sealing the site with an adhesive drape, and applying subatmospheric pressure (125 mmHg below ambient) that is transmitted to the wound in a controlled manner. Utilizing a pig model, four studies were undertaken to determine the effect of subatmospheric pressure on laser Doppler-measured blood flow in… 
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2,140 Citations
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Vacuum‐Assisted Closure: A New Method for Wound Control and Treatment: Clinical Experience
TLDR
A new subatmospheric pressure technique is presented: vacuum-assisted closure, which removes chronic edema, leading to increased localized blood flow, and the applied forces result in the enhanced formation of granulation tissue.
Vacuum-Assisted Closure: State of Basic Research and Physiologic Foundation
TLDR
A series of basic studies examining the use of subatmospheric pressure to treat wounds is presented, including the original studies upon which the vacuum-assisted closure device was based.
Effects of vacuum-assisted closure on wound microcirculation: an experimental study.
Mechanisms and Clinical Applications of the Vacuum-Assisted Closure (VAC) Device
TLDR
VAC has significantly increased the skin graft success rate when used as a bolster over the freshly skin-grafted wound, and is generally well tolerated and, with few contraindications or complications, is fast becoming a mainstay of current wound care.
New Techniques in Wound Management: Vacuum‐Assisted Wound Closure
  • L. Webb
  • Medicine
    The Journal of the American Academy of Orthopaedic Surgeons
  • 2002
TLDR
VAC has resulted in a low incidence of minor, reversible irritation to surrounding skin and no major complications, and further experience is required, as well as clinical and basic research, to define optimal indications and benefits compared with traditional methods of wound management.
Effects of vacuum‐assisted closure therapy on inguinal wound edge microvascular blood flow
TLDR
VAC therapy affects microvascular blood flow to the wound edge and may thereby promote wound healing and a low negative pressure during treatment may be beneficial, especially in soft tissue, to minimize possible ischemic effects.
Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model.
A Study of Vacuum Assisted Negative Pressure Therapy for Wound Healing
TLDR
VAC therapy enhanced granulation tissue formation leading to better wound healing, and faster recovery, and is thus a promising new technology in the field of wound healing with multiple applications in a variety of wounds.
The vacuum-assisted closure system for the treatment of deep sternal wound infections after cardiac surgery.
Blood flow responses in the peristernal thoracic wall during vacuum-assisted closure therapy.
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