Vacuole-localized berberine bridge enzyme-like proteins are required for a late step of nicotine biosynthesis in tobacco.

@article{Kajikawa2011VacuolelocalizedBB,
  title={Vacuole-localized berberine bridge enzyme-like proteins are required for a late step of nicotine biosynthesis in tobacco.},
  author={Masataka Kajikawa and Tsubasa Shoji and Akira Kato and Takashi Hashimoto},
  journal={Plant physiology},
  year={2011},
  volume={155 4},
  pages={2010-22}
}
Tobacco (Nicotiana tabacum) plants synthesize nicotine and related pyridine-type alkaloids, such as anatabine, in their roots and accumulate them in their aerial parts as chemical defenses against herbivores. Herbivory-induced jasmonate signaling activates structural genes for nicotine biosynthesis and transport by way of the NICOTINE (NIC) regulatory loci. The biosynthesis of tobacco alkaloids involves the condensation of an unidentified nicotinic acid-derived metabolite with the N… CONTINUE READING
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