Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity.

@article{Sennoune2004VacuolarHI,
  title={Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity.},
  author={Souad R. Sennoune and Karina Bakunts and Gloria M Mart{\'i}nez and Jenny L Chua-Tuan and Yamina Kebir and Mohamed N Attaya and Raul Mart{\'i}nez-Zaguil{\'a}n},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 6},
  pages={C1443-52}
}
Tumor cells thrive in a hypoxic microenvironment with an acidic extracellular pH. To survive in this harsh environment, tumor cells must exhibit a dynamic cytosolic pH regulatory system. We hypothesize that vacuolar H(+)-ATPases (V-ATPases) that normally reside in acidic organelles are also located at the cell surface, thus regulating cytosolic pH and exacerbating the migratory ability of metastatic cells. Immunocytochemical data revealed for the first time that V-ATPase is located at the… CONTINUE READING

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The matrix-degrading metalloproteinases

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