Vacuolar H+ -ATPase B1 subunit mutations that cause inherited distal renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting duct cells.

@article{Yang2006VacuolarH,
  title={Vacuolar H+ -ATPase B1 subunit mutations that cause inherited distal renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting duct cells.},
  author={Qiongqiong Yang and Guangmu Li and Satish Kumar Singh and Edward A. Alexander and John H. Schwartz},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 7},
  pages={1858-66}
}
Point mutations in the B1 subunit of vacuolar H+ -ATPase are associated with impaired ability of the distal nephron to secrete acid (distal renal tubular acidosis). For testing of the hypothesis that these mutations interfere with assembly and trafficking of the H+ -ATPase, constructs that mimic seven known point mutations in inherited distal renal tubular acidosis (M) or wild-type (WT) B1 were transfected into a rat inner medullary collecting duct cell line to express green fluorescence… CONTINUE READING

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