Vacuolar H(+)-ATPase localized in plasma membranes of malaria parasite cells, Plasmodium falciparum, is involved in regional acidification of parasitized erythrocytes.

@article{Hayashi2000VacuolarHL,
  title={Vacuolar H(+)-ATPase localized in plasma membranes of malaria parasite cells, Plasmodium falciparum, is involved in regional acidification of parasitized erythrocytes.},
  author={Mitsuko Hayashi and Hidenori Yamada and Toshihide Mitamura and Toshihiro Horii and Akitsugu Yamamoto and Yoshinori Moriyama},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 44},
  pages={34353-8}
}
Recent biochemical studies involving 2',7'-bis-(2-carboxyethyl)-5, 6-carboxylfluorescein (BCECF)-labeled saponin-permeabilized and parasitized erythrocytes indicated that malaria parasite cells maintain the resting cytoplasmic pH at about 7.3, and treatment with vacuolar proton-pump inhibitors reduces the resting pH to 6.7, suggesting proton extrusion from the parasite cells via vacuolar H(+)-ATPase (Saliba, K. J., and Kirk, K. (1999) J. Biol. Chem. 274, 33213-33219). In the present study, we… CONTINUE READING
34 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Malaria: Parasite Biology, Pathogenesis, and Protection (Scherman

  • N. J. White
  • I. W., ed.)
  • 1998

Plasma Membrane V-ATPase in P. falciparum

  • C. T. Atkinson, M. Aikawa
  • Blood Cells 16,
  • 1990

Similar Papers

Loading similar papers…