Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

@article{Forgac2007VacuolarAR,
  title={Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology},
  author={Michael Forgac},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={917-929}
}
  • M. Forgac
  • Published 1 November 2007
  • Biology
  • Nature Reviews Molecular Cell Biology
The acidity of intracellular compartments and the extracellular environment is crucial to various cellular processes, including membrane trafficking, protein degradation, bone resorption and sperm maturation. At the heart of regulating acidity are the vacuolar (V-)ATPases — large, multisubunit complexes that function as ATP-driven proton pumps. Their activity is controlled by regulating the assembly of the V-ATPase complex or by the dynamic regulation of V-ATPase expression on membrane surfaces… 
Regulation and isoform function of the V-ATPases.
TLDR
A number of mechanisms are employed to regulate V-ATPase activity in vivo, including reversible dissociation of the V(1) and V(0) domains, control of the tightness of coupling of proton transport and ATP hydrolysis, and selective targeting of V- ATPases to distinct cellular membranes.
Function, structure and regulation of the vacuolar (H+)-ATPases.
Regulation and function of V-ATPases in physiology and disease.
Recent Insights into the Structure, Regulation, and Function of the V-ATPases.
Vacuolar-type ATPases in animal and plant cells
Protons (H) play vital roles in bioenergetics and ion homeostasis, as evidenced by the presence of unique acidic compartments both inside and outside of cells. The acidification of compartments
The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation
TLDR
Cysteine-mediated cross-linking has been used to localize subunit isoforms within the V-ATPase complex and to investigate the helical interactions between subunits within the integral V0 domain.
Structure and regulation of the vacuolar ATPases.
The curious case of vacuolar ATPase: regulation of signaling pathways
TLDR
The direct role of V-ATPase in acidification and indirect regulation of signaling pathways, particularly Notch Signaling is discussed.
The Function of V-ATPases in Cancer.
TLDR
Of greatest excitement is evidence that at least some tumors express isoforms of V-ATPase subunits whose disruption is not lethal, leading to the possibility of developing anti-cancer therapeutics that selectively target V- ATPases that function in cancer cells.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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