Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors.

Abstract

Less than 200 years after its introduction, widespread use of vaccinia virus (VACV) as a smallpox vaccine has eradicated variola virus. Along with the remarkable success of the vaccination program, frequent and sometimes severe adverse reactions to VACV were encountered. After eradication, VACV has been reserved for select populations who might be at… (More)
DOI: 10.1586/erv.11.79

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