Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence

@inproceedings{Ferguson2013VacciniaVP,
  title={Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence},
  author={Brian J Ferguson and Camilla T. O. Benfield and Hongwei Ren and Vivian H. Lee and Gordon L. Frazer and Pavla Strnadova and Rebecca P. Sumner and Geoffrey L Smith},
  booktitle={The Journal of general virology},
  year={2013}
}
Vaccinia virus (VACV) expresses many proteins that are non-essential for virus replication but promote virulence by inhibiting components of the host immune response to infection. These immunomodulators include a family of proteins that have, or are predicted to have, a structure related to the B-cell lymphoma (Bcl)-2 protein. Five members of the VACV Bcl-2 family (N1, B14, A52, F1 and K7) have had their crystal structure solved, others have been characterized and a function assigned (C6, A46… CONTINUE READING