Vaccinia virus penetration requires cholesterol and results in specific viral envelope proteins associated with lipid rafts.

@article{Chung2005VacciniaVP,
  title={Vaccinia virus penetration requires cholesterol and results in specific viral envelope proteins associated with lipid rafts.},
  author={C S Chung and C. Huang and Wen Chien Chang},
  journal={Journal of virology},
  year={2005},
  volume={79 3},
  pages={1623-34}
}
Vaccinia virus infects a wide variety of mammalian cells from different hosts, but the mechanism of virus entry is not clearly defined. The mature intracellular vaccinia virus contains several envelope proteins mediating virion adsorption to cell surface glycosaminoglycans; however, it is not known how the bound virions initiate virion penetration into cells. For this study, we investigated the importance of plasma membrane lipid rafts in the mature intracellular vaccinia virus infection… CONTINUE READING
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