Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components.

@article{Waibler2009VacciniaVI,
  title={Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components.},
  author={Zoe Waibler and Martina Anzaghe and Theresa Frenz and Astrid Schwantes and Christopher P{\"o}hlmann and Holger Ludwig and Marcos Palomo-Otero and Antonio Alcam{\'i} and Gerd Sutter and Ulrich Kalinke},
  journal={Journal of virology},
  year={2009},
  volume={83 4},
  pages={1563-71}
}
Poxviruses such as virulent vaccinia virus (VACV) strain Western Reserve encode a broad range of immune modulators that interfere with host responses to infection. Upon more than 570 in vitro passages in chicken embryo fibroblasts (CEF), chorioallantois VACV Ankara (CVA) accumulated mutations that resulted in highly attenuated modified vaccinia virus Ankara (MVA). MVA infection of mice and of dendritic cells (DC) induced significant type I interferon (IFN) responses, whereas infection with VACV… CONTINUE READING
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