Vaccinia virus entry into cells is dependent on a virion surface protein encoded by the A28L gene.

@article{Senkevich2004VacciniaVE,
  title={Vaccinia virus entry into cells is dependent on a virion surface protein encoded by the A28L gene.},
  author={Tatiana G. Senkevich and Brian M. Ward and Bernard Moss},
  journal={Journal of virology},
  year={2004},
  volume={78 5},
  pages={2357-66}
}
The A28L gene of vaccinia virus is conserved in all poxviruses and encodes a protein that is anchored to the surface of infectious intracellular mature virions (IMV) and consequently lies beneath the additional envelope of extracellular virions. A conditional lethal recombinant vaccinia virus, vA28-HAi, with an inducible A28L gene, undergoes a single round of replication in the absence of inducer, producing IMV, as well as extracellular virions with actin tails, but fails to infect neighboring… CONTINUE READING