Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.

@article{Davies2005VacciniaVH,
  title={Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.},
  author={D. Huw Davies and Megan M. McCausland and Conrad David Valdez and Devan Huynh and Jenny E Hernandez and Yunxiang Mu and Siddiqua Hirst and Luis P. Villarreal and Philip L. Felgner and Shane Crotty},
  journal={Journal of virology},
  year={2005},
  volume={79 18},
  pages={11724-33}
}
The smallpox vaccine is the prototypic vaccine, yet the viral targets critical for vaccine-mediated protection remain unclear in humans. We have produced protein microarrays of a near-complete vaccinia proteome and used them to determine the major antigen specificities of the human humoral immune response to the smallpox vaccine (Dryvax). H3L, an… CONTINUE READING