Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.

@article{Gerlic2013VacciniaVF,
  title={Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.},
  author={Motti Gerlic and Benjamin Faustin and Antonio Postigo and Eric Chi-Wang Yu and Martina Proell and Naran Gombosuren and Maryla Krajewska and Rachel Flynn and Michael Croft and Michael Way and Arnold C. Satterthwait and Robert C. Liddington and Shahram Salek-Ardakani and Shu-ichi Matsuzawa and John C. Reed},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 19},
  pages={7808-13}
}
Host innate immune responses to DNA viruses involve members of the nucleotide-binding domain, leucine-rich repeat and pyrin domain containing protein (NLRP) family, which form "inflammasomes" that activate caspase-1, resulting in proteolytic activation of cytokines interleukin (IL)-1β and IL-18. We hypothesized that DNA viruses would target inflammasomes to… CONTINUE READING