Vaccinia virus F1L protein is a tail-anchored protein that functions at the mitochondria to inhibit apoptosis.

@article{Stewart2005VacciniaVF,
  title={Vaccinia virus F1L protein is a tail-anchored protein that functions at the mitochondria to inhibit apoptosis.},
  author={Tara Lynn Stewart and Shawn T. Wasilenko and Michele Barry},
  journal={Journal of virology},
  year={2005},
  volume={79 2},
  pages={1084-98}
}
Members of the poxvirus family encode multiple immune evasion proteins, including proteins that regulate apoptosis. We recently identified one such protein, F1L, encoded by vaccinia virus, the prototypic member of the poxvirus family. F1L localizes to the mitochondria and inhibits apoptosis by interfering with the release of cytochrome c, the pivotal commitment step in the apoptotic cascade. Sequence analysis of the F1L open reading frame revealed a C-terminal motif composed of a 12-amino-acid… CONTINUE READING