Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways.

@article{Myskiw2009VacciniaVE,
  title={Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways.},
  author={Chad Myskiw and Janilyn Arsenio and Rebekah van Bruggen and Yvon Deschambault and Jingxin Cao},
  journal={Journal of virology},
  year={2009},
  volume={83 13},
  pages={6757-68}
}
The vaccinia virus double-stranded RNA binding protein E3 has been demonstrated to inhibit the expression of cytokines, including beta interferon (IFN-beta) and tumor necrosis factor alpha (TNF-alpha). However, few details regarding the molecular mechanisms of this inhibition have been described. Using real-time PCR arrays, we found that E3 suppressed the induction of a diverse array of cytokines representing members of the IFN, interleukin (IL), TNF, and transforming growth factor cytokine… CONTINUE READING