Vaccinia virus A56/K2 fusion regulatory protein interacts with the A16 and G9 subunits of the entry fusion complex.

@article{Wagenaar2008VacciniaVA,
  title={Vaccinia virus A56/K2 fusion regulatory protein interacts with the A16 and G9 subunits of the entry fusion complex.},
  author={Timothy Robert Wagenaar and Suany Ojeda and Bernard Moss},
  journal={Journal of virology},
  year={2008},
  volume={82 11},
  pages={5153-60}
}
Deletion of the A56R or K2L gene of vaccinia virus (VACV) results in the spontaneous fusion of infected cells to form large multinucleated syncytia. A56 and K2 polypeptides bind to one another (A56/K2) and together are required for interaction with the VACV entry fusion complex (EFC); this association has been proposed to prevent the fusion of infected cells. At least eight viral polypeptides comprise the EFC, but no information has been available regarding their interactions either with each… CONTINUE READING

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